Nucleic acid charge transfer: Black, white and gray

The Genome in Black and White (and Gray)

That's about to change. In the not-too-distant future, if you're black and have heart failure, drug-company researchers predict you'll be able to go to the doctor and walk out with a prescription tailor-made for you. Well, not tailor-made, exactly, but something that seems to work in people a lot like you. Well, not a lot like you, exactly, except that they're black, too. In this not-too-distan...

Diagnosis of acromegaly: black, white… and sometimes gray!

SOA Testing using Black, White and Gray Box Techniques

Web Services are the foundations of modern Service Oriented Architecture (SOA). Typical Web Services include message exchange between a consumer and a producer using SOAP request and responses over the ubiquitous HTTP protocol. A Web service producer advertises its services to potential consumers through Web Services Description Language (WSDL) – an XML file that contains details of available o...

Effect of backbone flexibility on charge transfer rates in peptide nucleic acid duplexes.

Charge transfer (CT) properties are compared between peptide nucleic acid structures with an aminoethylglycine backbone (aeg-PNA) and those with a γ-methylated backbone (γ-PNA). The common aeg-PNA is an achiral molecule with a flexible structure, whereas γ-PNA is a chiral molecule with a significantly more rigid structure than aeg-PNA. Electrochemical measurements show that the CT rate constant...

Evidence for a near-resonant charge transfer mechanism for double-stranded peptide nucleic acid.

We present evidence for a near-resonant mechanism of charge transfer in short peptide nucleic acid (PNA) duplexes obtained through electrochemical, STM break junction (STM-BJ), and computational studies. A seven base pair (7-bp) PNA duplex with the sequence (TA)(3)-(XY)-(TA)(3) was studied, in which XY is a complementary nucleobase pair. The experiments showed that the heterogeneous charge tran...